Dra. Daniela Millán Retamal

Diseño y síntesis de disolventes alternativos para usarlos en procesos químicos tales como, extracción de compuestos bioactivos, preparación de geles, extracción de lignina. Efecto del disolvente sobre mecanismos y velocidades de reacción.

1. Fondecyt Regular: New insights into delignification with sustainable solvents (2023-2027)
2. Proyecto Interno UBO: Extracción de Saponinas del Quillay usando solventes de eutéctico profundo.(2022)
3. Fondecyt Postdoctorado: Patrocinante de la postdoctorada Lucy Muruchi (2020 – 2023)
4. Proyecto interno UBO: Extracción de compuestos bioactivos de la Lúcuma y Chirimoya usando solventes de eutéctico profundo (2018 – 2019)
5. Fondecyt de Iniciación en Investigación: Alternative greener solvents to pre-treatment of lignocellulosic biomass (2017 – 2021)
6. Fondecyt postdoctorado: Green solvents to nucleophilic degradation of organophosphorous pesticides (2014 – 2018)
7. Fondef IDEA (Profesor Asociado): Diseño de solventes verdes para obtención de nanocelulosa. (2018 – 2021)

1. Millán, D.; Almeida, M.; Rufino, A. F.; Coutinho, J. A. P.; Freire, M. G. Nucleophilic Degradation of Diazinon in Thermoreversible Polymer-Polymer Aqueous Biphasic Systems. Phys. Chem. Chem. Phys. 2021. [link]
2. Millán, D.; Rojas, M.; Tapia, R. A.; Pavez, P. Microwave-Assisted Nucleophilic Degradation of Organophosphorus Pesticides in Propylene Carbonate. Org. Biomol. Chem. 2020, 18 (39), 7868–7875. [link]
3. Pavez, P.; Figueroa, R.; Medina, M.; Millán, D.; Falcone, R. D.; Tapia, R. A. Choline [Amino Acid] Ionic Liquid/Water Mixtures: A Triple Effect for the Degradation of an Organophosphorus Pesticide. ACS Omega 2020, 5 (41), 26562–26572. [link]
4. Millán, D.; Tapia, R. A.; Pavez, P. Efficient Nucleophilic Degradation of an Organophosphorus Pesticide “Diazinon” Mediated by Green Solvents and Microwave Heating. Front. Chem. 2019, 6, 669. [link]
5. Morales, J. I.; Figueroa, R.; Rojas, M.; Millán, D.; Tapia, R. A.; Pavez, P. Dual Function of Amino Acid Ionic Liquids (Bmim[AA]) on the Degradation of the Organophosphorus Pesticide{,} Paraoxon®. Org. Biomol. Chem. 2018, 16 (40), 7446–7453. [link]
6. Rizzo, C.; Marullo, S.; Campodonico, P. R.; Pibiri, I.; Dintcheva, N. T.; Noto, R.; Millán, D.; D’Anna, F. Self-Sustaining Supramolecular Ionic Liquid Gels for Dye Adsorption. ACS Sustain. Chem. Eng. 2018, 6 (9), 12453–12462. [link]
7. Pavez, P.; Honores, J.; Millán, D.; Isaacs, M. UN Sustainable Development Goals: How Can Sustainable/Green Chemistry Contribute? Curr. Opin. Green Sustain. Chem. 2018, 13, 154–157. [link]
8. Pavez, P.; Millán, D.; Morales, J.; Rojas, M.; Céspedes, D.; Santos, J. G. Reaction Mechanisms in Ionic Liquids: The Kinetics and Mechanism of the Reaction of O{,}O-Diethyl (2{,}4-Dinitrophenyl) Phosphate Triester with Secondary Alicyclic Amines. Org. Biomol. Chem. 2016, 14 (4), 1421–1427. [link]
9. Pavez, P.; Millán, D.; Morales, J.; Rojas, M.; Céspedes, D.; Santos, J. G. Correction: Reaction Mechanisms in Ionic Liquids: The Kinetics and Mechanism of the Reaction of O{,}O-Diethyl (2{,}4-Dinitrophenyl) Phosphate Triester with Secondary Alicyclic Amines. Org. Biomol. Chem. 2016, 14 (4), 1502. [link]
10. Pavez, P.; Millán, D.; Rojas, M.; Morales, J. I.; Santos, J. G. Reaction Mechanism in Ionic Liquids: Kinetics and Mechanism of the Aminolysis of 4-Nitrophenyl Acetate. Int. J. Chem. Kinet. 2016, 48 (6), 337–343. [link]
11. Pavez, P.; Oliva, G.; Millán, D. Green Solvents as a Promising Approach to Degradation of Organophosphorate Pesticides. ACS Sustain. Chem. Eng. 2016, 4 (12), 7023–7031. [link]
12. D’Anna, F.; Millán, D.; Noto, R. The Ionic Liquid Effect on the Boulton–Katritzky Reaction: A Comparison between Substrates of Different Structure. Tetrahedron 2015, 71 (39), 7361–7366. [link]
13. Pavez, P.; Millán, D.; Cocq, C.; Santos, J. G.; Nome, F. Ionic Liquids: Anion Effect on the Reaction of O{,}O-Diethyl O-(2{,}4-Dinitrophenyl) Phosphate Triester with Piperidine. New J. Chem. 2015, 39 (3), 1953–1959. [link]
14. Aliaga, M. E.; Tiznado, W.; Cassels, B. K.; Nuñez, M. T.; Millán, D.; Pérez, E. G.; García-Beltrán, O.; Pavez, P. Substituent Effects on Reactivity of 3-Cinnamoylcoumarins with Thiols of Biological Interest. RSC Adv. 2014, 4 (2), 697–704. https://doi.org/10.1039/C3RA44695F
15. Millán, D.; Rojas, M.; Santos, J. G.; Morales, J.; Isaacs, M.; Diaz, C.; Pavez, P. Toward a PKa Scale of N-Base Amines in Ionic Liquids. J. Phys. Chem. B 2014, 118 (16), 4412–4418. [link]
16. Millán, D.; Rojas, M.; Pavez, P.; Isaacs, M.; Diaz, C.; Santos, J. G. Influence of the Ionic Liquid on the Rate and the Mechanism of Reaction of P-Nitrophenyl Acetate with Secondary Alicyclic Amines. New J. Chem. 2013, 37 (10), 3281–3288. [link]
17. Pavez, P.; Millán, D.; Morales, J. I.; Castro, E. A.; López A., C.; Santos, J. G. Mechanisms of Degradation of Paraoxon in Different Ionic Liquids. J. Org. Chem. 2013, 78 (19), 9670–9676. [link]
18. Millán, D.; Santos, J. G.; Castro, E. A. Kinetic Study of Solvent Effects on the Aminolysis of O-Ethyl S-Aryl Dithiocarbonates. J. Phys. Org. Chem. 2012, 25 (11), 989–993. [link]
19. García-Beltrán, O.; González, C.; Pérez, E. G.; Cassels, B. K.; Santos, J. G.; Millán, D.; Mena, N.; Pavez, P.; Aliaga, M. E. Nucleophilic Reactivity of Biothiols toward Coumarin-Based Derivatives Containing a Chalcone Moiety. J. Phys. Org. Chem. 2012, 25 (11), 946–952. [link]
20. Ormazábal-Toledo, R.; Castro, E. A.; Santos, J. G.; Millán, D.; Cañete, A.; Contreras, R.; Campodónico, P. R. Predicting the Reaction Mechanism of Nucleophilic Substitutions at Carbonyl and Thiocarbonyl Centres of Esters and Thioesters. J. Phys. Org. Chem. 2012, 1359-1364. [link]
21. Rezende, M. C.; Dominguez, M.; Aracena, A.; Millán, D. Solvatochromism and Electrophilicity. Chem. Phys. Lett. 2011, 514 (4), 267–273. [link]
22. Rezende, M. C.; Millán, D. Theoretical Substituent Electrophilicities. J. Braz. Chem. Soc. 2011, 22, 2078–2086. [link]
23. Castro, E. A.; Millán, D.; Aguayo, R.; Campodónico, P. R.; Santos, J. G. Reactions of Aryl Acetates with Secondary Alicyclic Amines in Ethanol/Water Mixtures: Effect of the Solvent Composition on the Kinetics and Mechanism. Int. J. Chem. Kinet. 2011, 43 (12), 687–693. [link]
24. Rezende, M. C.; Oñate, R.; Domínguez, M.; Millán, D. Solvatochromism and Halochromism of N-(4-Oxyphenyl) 5-Nitro-2-Thiophenecarboxaldimine. Spectrosc. Lett. 2009, 42 (2), 81–86. [link]
25. Millán, D.; Domínguez, M.; Rezende, M. C. Solvatochromic Hydrazone Anions Derived from Chalcones. Dye. Pigment. 2008, 77 (2), 441–445. [link]
26. Rezende, M. C.; Pizarro, C.; Millán, D. Preparation, Spectroscopic and Acidity Properties of Two Hydrazones: An Organic Lab Experiment. QuÃ\-mica Nov. 2007, 30, 229–231. [link]
27. Mayra A. Mariño , Maria G. Paredes , Natalia Martinez , Daniela Millan , Ricardo A. Tapia , Domingo Ruiz  , Mauricio Isaacs  and Paulina Pavez, 2023, A ternary eutectic solvent for cellulose nanocrystal production: exploring the recyclability and pre-pilot scale-up, Front. Chem. 11:1233889, https://www.frontiersin.org/articles/10.3389/fchem.2023.1233889/full
28. Daniela Millán, Cristian Malebrán, Rodrigo Ormazábal-Toledo,  2023, “Towards a rational design of natural deep eutectic solvents for the extraction of polyphenols from Luma apiculata”, 373, 121155. Towards a rational design of natural deep eutectic solvents for the extraction of polyphenols from Luma apiculata – ScienceDirect
29. Daniela Millán, Felipe González-Turen, Josei Perez-Recabarren, Christopher Gonzalez-Ponce, Marcos Caroli Rezende, André M. Da Costa Lopes,” Solvent effect on the wood delignification with sustainable solvents”, International Journal of Biological Macromolecules, 2022, 211, 490-498. Solvent effects on the wood delignification with sustainable solvents – ScienceDirect
30. Vanderlei Gageiro Machado, Daniela Millán, Marcos Caroli Rezende: “Binary Mixtures with Deep Eutectic Solvents: Comparing Properties with a Non–Ideality Approach, Journal of Molecular Liquids, 2022, 359, 119259. Binary mixtures with deep eutectic Solvents: Comparing properties with a Non–Ideality approach – ScienceDirect
31. Daniela Millán, Uros Novack, Andre M. Da Costa Lopes, Editorial: Green and sustainable solutions for fractionating lignocellulosic biomass, Frontiers in Chemistry, 2021, 9, 803431. Frontiers | Editorial: Green and Sustainable Solutions for Fractionating Lignocellulosic Biomass (frontiersin.org)
32. Daniela Millán, Mafalda R. Almeida,  Ana F.C.S. Rufino, João A.P. Coutinho, Mara G. Freire,  Phys. Chem. Chem. Phys., 2021, 23, 4133. Microwave-assisted nucleophilic degradation of organophosphorus pesticides in propylene carbonate – Organic & Biomolecular Chemistry (RSC Publishing)
33. Daniela Millán, Mabel Rojas, Paulina Pavez, Ricardo Tapia. 2020, Org. Biomol. Chem, , 18, 7868. Nucleophilic degradation of diazinon in thermoreversible polymer–polymer aqueous biphasic systems – Physical Chemistry Chemical Physics (RSC Publishing)
34. Paulina Pavez, Roberto Figueroa, Mayte Medina, Daniela Millán, Dario Falcone, Ricardo Tapia. ACS Omega 2020, 5, 26562. Choline [Amino Acid] Ionic Liquid/Water Mixtures: A Triple Effect for the Degradation of an Organophosphorus Pesticide | ACS Omega
35. Daniela Millan, Ricardo Tapia, Paulina Pavez, Frontiers in Chemistry, 2019, 6, 669. 10.3389/fchem.2018.00669
36. Paulina Pavez, Jessica honores, Daniela Millán, Mauricio Isaacs, Current Opinion in Green and Sustainable Chemistry, 2018, 13,154. 10.1016/j.cogsc.2018.06.013
37. Carla Rizzo, Salvatore Marullo, Paola R. Campodónico, Ivana Pibiri, Nadka Tz. Dintcheva, Renato Noto, Daniela Millán, and Francesca D’Anna, ACS Sustainable Chemistry & Engineering, 2018, 6 (9), 12453. 10.1021/acssuschemeng.8b03002
38. Javiera Morales, Roberto Figueroa, Mabel Rojas, Daniela Millán, Ricardo Tapia, Paulina Pavez, Org. Biomol. Chem., 2018, 16, 7446. 10.1039/C8OB01928B

• Mario Castillo, Daniela Millán, Teresa Poblete (2023),Extraccion de saponinas usando solventes de eutéctico profundo.CHILE. 202301296.
• Daniela Millán, Cristian Malebrán, Felipe González, Rodrigo Ormazábal. (2022). Extracción de compuestos fenólicos de arrayán rojo (luma apiculata) empleando un solvente de eutéctico profundo. 1584-2022. CHILE
• Mauricio Isaacs, Paulina Pavez, Cesar Sáez, Ricardo Tapia, Daniela Millán, Carlos Diaz, Mayra Mariño.(2022) Método de preparación de nano celulosa usando solvente verdes especialmente sintetizados. Wo 2022/027150 A1
• Daniela Millán, Soledad Vidaurre (2020), Método de obtención de un extracto de lúcuma empleando un solvente de eutéctico profundo (DES), el extracto obtenido y su uso como antioxidante y antiproliferativo. Solicitud No. 2376-2020. CHILE